A modified frequency domain optical coherence tomography procedure for imaging severely stenotic coronary artery lesions

Feng Tian, Ying Zhou, Yundai Chen, Jing Wang, Shanshan Zhou, Tao Zhang

Abstract
Aims: This proof-of-concept study aimed to investigate the clinical feasibility of a modified frequency domain optical coherence tomography (FD-OCT) procedure for imaging severely stenotic coronary artery lesions.


Methods and results:
In total, 46 patients in whom clear images were unobtainable using conventional FD-OCT examination were consecutively enrolled in this study. Then, they were randomly divided into two groups: group A (FD-OCT examination using the new modified procedure, n=23), and group B (FD-OCT examination using a previously described procedure, the Yamaguchi method, n=23). The procedure success was 100% in group A and 86.96% in group B. Clear images of the proximal segment were obtained by both procedures for all patients. The percentage of clear images for the distal segment was 95.65% in group A and 85% in group B. Clear images of the maximal stenosis segment were 100% in group A and 95% in group B. However, these outcomes were not significantly different between the two groups. The amount of contrast agent used in group A was lower than that used in group B.


Conclusions:
The new modified procedure can obtain clear images of severely stenotic coronary artery lesions. The difference in contrast volume is of statistical significance but may be of minimal clinical significance.

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