Imaging outcomes of bioresorbable scaffold overlap: an optical coherence tomography analysis from the ABSORB EXTEND trial
Yohei Sotomi, Pannipa Suwannasom, Chiung-Jen Wu, Hiroki Tateishi, Wai-Fung Cheong, Wei-Ying Zhao, Susan Veldhof, Robbert J. de Winter, Joanna J. Wykrzykowska, Vasim Farooq, Alexandre Abizaid, Patrick W Serruys, Yoshinobu Onuma
Aims: The purpose of this study was to assess the vascular response and vessel healing of overlapped Absorb scaffolds (Abbott Vascular, Santa Clara, CA, USA) compared to non-overlapped devices in human coronary arteries as assessed by optical coherence tomography (OCT) in the same treated segment.
Methods and results: The ABSORB EXTEND (NCT01023789) trial is a prospective, single-arm, openlabel clinical study which enrolled 800 patients. The planned overlap OCT subgroup in the ABSORB EXTEND trial was analysed and two-year OCT follow-up was performed in seven patients. In cross-section level analysis at baseline, lumen and abluminal scaffold areas were larger in overlap segments than in nonoverlap segments, whereas the endoluminal scaffold area was similar. At two-year follow-up, lumen area and endoluminal scaffold areas were similar in both segments despite the neointimal area being larger in the overlap segments. The neointimal coverage was essentially fully complete in both non-overlap (99.4±0.8%) and overlap segments (99.8±0.4%) at two-year follow-up.
Conclusions: The imaging results of this small OCT subgroup analysis in the ABSORB EXTEND trial demonstrated substantial vessel healing and vascular response in the overlap segments of Absorb at twoyear follow-up comparable to the non-overlap segments.
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